Introduction : Fluid shear stress (pulsatile and laminar) and pressure comprise of the two in vivo physical forces to which vascular endothelium is constantly exposed. Besides. vasodilator and autacoids. nitric oxide is the main endothelium derived relaxing factor (EDRF) released in response to alterations in blood pressure and shear stress. https://unitedssports.shop/product-category/bike-parts-tubes/